ZONULIN AND SOME PARAMETERS AS EARLY BIOMARKERS OF PREGNANCY-INDUCED HYPERTENSION IN IRAQ

Zonulin, Erythropoietin, Prolidase and increase in level (P<0.01) but Renalase decrease in the levels(P<0.01) a implicated in several metabolic disorders including hypertension , obesity and vascular weakness . The purpose of the current study was to estimate the serum erythropoietin , zonulin , Renalase content of pregnant women with preeclampsia caused by hypertension and obesity. Pregnancy induced hypertension which includes preeclampsia and gestational hypertension There is a relationship linking collagen formation to the proportion of prolidase. The deficiency in this enzyme is a genetic condition that occurs due to mutations in the PEPD gene on the nineteenth chromosome and in some pathological cases. Preeclampsia is one of the social problems in the world in general and in Iraq in particular, as a result of the psychological, economic and environmental conditions lived by the family. This study was done to Find the levels of these biochemical parameters of tight junction regulation among women with gestational hypertension.