HISTOLOGICAL STUDY OF THE THERAPEUTIC EFFECT OF BETA-AMINO BUTYRIC ACID ON INFLAMMATION OF SKIN INJURY CAUSED BY PSEUDOMONAS AERUGINOSA

Background: The present work aims to indicate the therapeutic role of Beta-amino butyric acid on skin bacterial infection, using pseudomonas aeruginosa for the indicated infection. Materials and methods: Using (40) healthy female Waster albino rats, ten (10) control groups without infection (Group A), ten (10) infected groups without dealing with beta-aminobutyric acid (Group B), and ten (10) infected groups (C, D), ten rats in each group dealing with amino acid Infection was induced by making a skin scare at the end of the head using pseudomonas aeruginosa bacteria. For treatment using 25mg/ml and 50mg/ml of beta-amino butyric acid by intraperitoneal injection for experimental groups. Results: The results of the study revealed the treatment role of beta-amino butyric acid in infected wounds by pseudomonas aeruginosa and its effect on bacterial growth. The sections of skin of group (A) show normal appearance without any changes in skin tissue; while group (B) recorded damage of the skin tissue layers due to infection by pseudomonas aeruginosa. Groups C and D revealed healing of injury and treated the bacterial infection at different levels. Low concentrations (25mg/ml) of amino acid show rapid positive results for the treatment of infection and healing of injury compared with higher concentrations (50mg/ml) of amino acid.