Research article

SYNTHESIS OF 2-ALKYL OR 2-ARYL BENZOFURAN SUBSTITUTED IMIDAZOL THIADIAZOLES

Sakshi Sharma a, Ravi Kumar Rana a*

Online First: November 30, 2022


The 1,3,4-thiadiazole family of compounds is crucial for the creation of novel pharmaceuticals. They possess fascinating pharmacophore that exhibit a wide range of biological activities. An intriguing building block that has been utilized to create a number of beneficial bioactive chemicals is the 1,3,4-thiadiazole scaffold. Because of the durability of the thiadiazole nucleus, medicinal chemists have altered the ring's structure in numerous ways. Two thiadiazole derivatives were synthesized using different reagents and procedures and then were evaluated to check their antibacterial; and antifungal activity. Both the compounds were synthesized and characterized using IR. The compounds were found to possess antibacterial and antifungal activity to a good extent. They were effective against two out of three bacterial strains that we used to test. Thiadiazole derivative can be effective and potent candidates for antimicrobial activity and can be further used to treat microbial infections.

Keywords

1,3,4-thiadiazole, Antimicrobial, Antifungal activity, heterocyclic compounds