IN VITRO ANTIOXIDANT ACTIVITY OF ZINC OXIDE NANOPARTICLES PREPARED USING SYMPLOCOSRACEMOSA (LODHRA) AND CINNAMOMUM CASSIA (CINNAMON) FORMULATION

Background: Nanotechnology, the branch of science, which has application in medicine with a 1–100 nm dimension range which is known as nanomedicine. Zinc Oxide nanoparticles are an essential part in diagnostics, biomolecular location, and microelectronics. Nanoparticles synthesized by natural products have become significant due to their ease and biodegradability. Aim: The main aim of this study was to employ Symplocosracemose (lodhra) and Cinnamomum cassia (cinnamon) extract in the formulation of zinc oxide nanoparticles and check the antioxidant activity Materials and methods:Lodhra bark and cinnamon were collected. One gram of Lodhra and cinnamon bark is blended with 100 ml of distilled water and boiled for 3-5 mins in a heating mantle and separated by using filter paper. The lodhra formulation is added to the zinc Nitrate fine particles that are mixed in distilled water. Formulation is kept in vibrator and for every 2 hrs the values were taken for analyzing the nanoparticles. SymplocosRacemosa mediated copper nanoparticles were characterized by UV-Visible spectrophotometer and TEM. Further the SymplocosRacemosa mediated nanoparticles were subjected to DPPH assay to determine the antioxidant activity. Results:The herbal formulation showed a maximum of 85% antioxidant activity which is significantly equivalent to standard i.e. ascorbic acid(90%) against DPPH assay. It is also evident that as the volume of the nanoparticles increases, there will be an increase in the antioxidant activity. Conclusion:Zinc oxide nanoparticles using lodhra, cinnamon bark extract. The synthesis zinc oxide nanoparticles showed significant antioxidant activity along with standard i.e. ascorbic acid in DPPH free radicals and H2O2 assay. ZnO Np are economical, easy and biodegradable products, which could be developed into different pharmaceutical areas.