Research article

Evaluation of certain serum trace element levels in patients with acute and chronic leukemia

Omar H. A. Abuhmid1, Sukayna H. Rashed2

Online First: November 08, 2022

The study's major focus was on how trace elements were distributed in blood samples from patients with leukemia.The current study focuses on assessing potential connections between trace elements and acute and chronic kinds of leukemia through the measurement of their amounts in blood serum. In patients, Cd was found at sub-ppm levels, with Mg being the main contributor at mean levels. The mineral copper plays a crucial role in controlling the body's metabolism, which is necessary for a variety of biological processes. Generally speaking, an increased risk of malignancies, particularly blood cancers, is associated with iron deficiency. It can be crucial if the body's level of it changes noticeably. The current study measured the amounts of copper, magnesium, iron, and cadmium in the sera of leukemia patients who had been referred to Mosul Hospitals and compared the results with a control group's findings. Evaluation included 30 healthy people and 60 leukemia patients. Patients were divided into groups with acute and chronic leukemia. Both the control group and the patients' blood was drawn. using the flame atomic absorption technique, copper and cadimium levels in the sera were determined, while magnesium and iron were measured coloremetrically. 31 (51.66%) men and 29 (48.33%) women made up the patient population, whereas 15 (50%) men and 15 (50%) women made up the healthy participants. The average age of those in the patient group was 22.5 years, whereas that of those in the control group was 23.9 years. The age ranges for the case group and the control group were 3-71 years and 2-79 years, respectively. Acute leukemia (30 instances) and chronic leukemia were among the patients in the cohort (30 cases). Serum copper levels in patients were noticeably higher (p˂ 0.001) when compared to controls. An enormous rise in the levels of copper, cadmium, and iron, and a slight and insignificant decrease in the rates of magnesium concentrations in leukemia patients compared with healthy subjects. Evidence of elevated levels of Cu, Cd and Fe was observed in leukemia patients, which could imply that these substances play a function in cancer as a distinctive risk factor for malignancy.


: Leukemia, Copper, Cadimium, Iron, Magnesium