FABRICATION AND EFFECT OF THE GOLD NANOPARTICLE BY A CHEMICAL METHOD ON MEDICAL PHYSICS APPLICATIONS

Gold nanoparticles (AuNPs) were chemically synthesised. Their surface plasmon resonance is shifted chemically to the near-infrared spectrum. The structure of the synthesised AuNPs was examined using X-ray diffraction, transmission electron microscopy (TEM), and ultraviolet-visible spectroscopy, and they were evaluated using their zeta potential. Reducing agents were used to create the AuNP solution. The diffraction lines at 38.2°, 44.4°, 64.5°, and 77.6° correspond to the (111), (200), (220), and (311) crystal planes in their XRD patterns. As the ratio increased, the lines’ width shrank, suggesting that their crystallite size had increased. The TEM image was used to assess the synthesised AuNP’s size and shape, which had an average diameter of 14.73 nm and a stability of −27.1 mV. The AuNP’s antibacterial activity against Proteus mirabilis and Streptococcus mutans was assessed at four dilutions (12.5%, 25%, 50%, and 100%), showing broad inhibition zones (16, 18, 21, and 23 mm) and (12, 16, 18, and 21 mm), respectively; note that the control well diameter was 6 mm AuNPs were also more effective against breast cancer cell, showing a significant cell-killing effect on them at 100 µg/mL, with a cell survival rate of 48.74%. Importantly, this concentration was below the killing threshold for normal breast cells.