FABRICATION, CHARACTERIZATION AND ANTICANCER ACTIVITIES OF GOLD & VIOLA (VIOLA ODORATA) BASED GREEN NANOPARTICLES

Nano biotechnology has opened new ways of improved materials in biomedical integrations. Green synthesis with noble metals is an enormously emerging area of research in a Nano biotechnology. It acknowledged great consideration from physicists, chemists, engineers and bio scientists who wish for the development of a new world Nano medicines. The current contribution deals with one pot synthesis of green nanoparticles by gold via potent and traditional medicinal plant Viola odorata.The synthesized nanoparticles were characterized via different analytical procedures, included ultraviolet-visible spectroscopy(UV), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction(XRD) and scanning electron microscopy (SEM). The ultra violet-visible spectrum of nanoparticles e.g VGNPs peaks were recorded at 530nm. Optimization has gained at pH 8-9, 1mM conc., high heat and 48 hrs incubation period along with pH 9-10 and 3mM conc. enhanced the gold nanoparticles synthesis and small size. FTIR studies revealed some alcoholic and phenyl groups are involved in capping of viola based GNPs. XRD and SEM confirmed the particles size and shape were found spherical and triangular for VGNPs size varied from 42-60nm. VGNPs proved best allaround for bioactivities like antileshminial, haemolysis studies, cytotoxicity testing and anticancer assey studies proved promising activity for VERO cells while also for MCF-7 breast cancer cell lines.The outcome of the recent reserch could make a way in the development of value-added products from viola odorata with metallic salts of gold for biomedical, agriculture and nanotechnology-based productions.