DETERMINATION THE RELATIONSHIP BETWEEN IL-38 AND IL-17 IN REDUCING THE SEVERITY OF PSORIASIS IN SAMPLES OF IRAQI PATIENTS

This study was aimed to determine the relationship between level of Interleukin-38 and Interleukin-17 in psoriasis, one hundred-five patients, twenty-five of them suffering from psoriasis and twenty-two of them suffering from psoriasis and Helicobacter pylori who attended at Dermatological Clinic and fifty-eight patients who infected with Helicobacter pylori take from Al-kindi Hospital, Kadhimiya Teaching Hospital, AL-Yarmouk Teaching Hospital and AL-Zahra Hospital. Aged (≤ 35, >35) years have been investigated and compared to Twenty-five samples of apparently healthy individuals were studied as control group. All the studied groups were subjected to measurement level of IL-38 and IL-17 by Enzyme linked immunosorbent assay (ELISA). The results of current study revealed that there was a highly significant elevation (P0.0001) between level of IL-38 and IL-17 in sera of patients. Conclusion, IL-17 play critical role in the pathogenesis of psoriasis. The highest level of IL-17 in patients' serum was in patients whose infected with psoriasis and Helicobacter pylori together, IL-38 act as protective factor in psoriasis and there was a negative relationship between level of IL-17 and IL-38.