THE INFLUENCE OF CISSUS QUADRANGULARIS WITH MESENCHYMAL STEM CELLS FROM DENTAL PULP ON BONE REGENERATION

Background Recently, Plant Derivatives in Tissue Engineering have demonstrated regenerative potential, but the real effect remains to be examined. This pilot study attempted to isolate dental pulp stem cells from four patients and to evaluate the feasibility and the effect of reconstructing periodontal intrabone defects in each patient using its combination with cissus quadrangularis extract and alone. Methods In this split mouth study ,DPSCs-Ps were harvested from four patients with bilateral periodontal intrabone defects with their approval. After discussing the biological characteristics of DPSCs-Ps in each patient, DPSCs-Ps were loaded onto the scaffold material cissus quadrangularis extract and engrafted into the periodontal defect area in the root furcation in one side and another side was filled with DPSCs-P with collagen sponge. Results We observed 78±27 % bone fill with DPSC-P /CQ extract complex in comparison to 71±18% in DPSc’s –P alone.