STUDY THE EFFECT OF MALONDIALDEHYDE AND SOME IMPORTANT HORMONES (INSULIN, CORTISOL, ADRENOCORTICOTROPIC, TESTOSTERONE & ESTROGEN) IN (FACE & SHOULDER) ACNE PATIENTS IN BASRAH GOVERN

Background: Acne is associated with lifestyle and environmental changes, as it is considered a source of anxiety due to the high rate of its occurrence and its impact on the basis of social life and psychological state of the patient. Acne vulgaris is an inflammatory disease that affects the oily hair follicles. It appears frequently in adolescents on the forehead in the form of white or black heads. It can also become more complicated with atrophic or enlarged scars. Aim: of this study is to assessing the effect of oxidative free radicals through the malondialdehyde biomarker, and investigate the role of hormones, as their levels imbalance contributes to acne. Results: In the Face acne patients: (MDA, insulin & testosterone) showed highly significant increase comparing to the control group. The probability (𝑃 < 0.05), was considered statistically significant. Comparing statistical results between males and females in the face acne shows: (MDA & estrogen) showed highly significant increase. While (ACTH & testosterone) showed highly significant decrease. Using (ROC) curve for patients with face acne, females show highly significant statistical behavior for (MDA & ACTH), with high percentage of the area under the curve and good characteristic of validity for all tests. While males show highly significant statistical behavior for (MDA), with high percentage of the area under the curve and good characteristic of validity for all tests. In the Shoulder acne patients: (MDA) showed highly significant increase comparing to the control group, while cortisol showed highly significant decrease comparing to the control group. Comparing statistical results between males and females in the shoulder acne, (ACTH & estrogen) showed highly significant increase. While testosterone showed highly significant decrease. Spearman's nonparametric statistical correlation coefficient for biomarkers, in all patients with (face & shoulder) acne, shows different correlations as showed in the tables. Conclusion: The study correlate between biochemical markers with gender and acne site in a group of participants. The results show statistically significant behavior between them, and reflected the body physiology, skin type, and hormonal predominance on acne. Abbreviations used: MDA: Malondialdehyde, ACTH, Adrenocorticotropic and ROC, receiver operating characteristic.