USES OF FENUGREEK (TRIGONELLA FOENUM) LEAVES ALCOHOLIC EXTRACT IN TREATMENT OF HEMATOTOXICITY INDUCED BY ACETAMINOPHEN IN MALE RATS

The current study was proceed to analysis the therapeutic effects of Fenugreek leaves extract (FSE) on renal defect experimentally induced by by acetaminophen oral administration for 14 consecutive days. After that T1 and T2 received 150mg/kg.bw and 300mg/kg.bw respectively for 14 consecutive days while control positive group (C+) leave without any treatment. Forty male rats divided into 4 groups as follow: C-, C+,T1 and T2. The results showed Significant increase (P ≤ 0.05) in blood parameters such as RBC, MCH% , , Hb, Granulocyte and MID%, in animals groups were treated with FSE. On the other hand WBCs and lymphocytes significantly (P ≤ 0.05) decrease in T1 and T2 groups when compared with C+ group. In conclusion, fenugreek extract has good therapeutic effects on biochemical and hematological parameters depending on dose and concentration of extract as well as arise clearly in nourishment of kidney and liver tissue.