BIOFABRICATION OF ZINC OXIDE NANOPARTICLES USING CINNAMON AND LODHRA BARK FORMULATION AND ITS ANTI INFLAMMATORY ACTIVITY.

Aim:The aim of this study is to analyze the anti-inflammatory effect of zinc oxide nanoparticles using lodhra and cinnamon bark extract . Introduction: In the current situation, focus on plant research has been increased all over the world and much evidence has been collected to show the potential of medicinal plants. They are used for treating various bacterial and fungal infections and could lead to development of potential herbal medicine. They are more effective for the treatment of infectious disease with least side effects. Plant extract has the significant anti-inflammatory nature of which helps in the quick recovery of the patients and much research has been done. Materials and methods: Fresh lodhra bark and cinnamon powder was collected. 1g of freshly collected Lodhra and cinnamon bark extract is mixed with 100 ml of distilled water thoroughly and boiled for 3-5 mins in a heating mantle then filtered by using filter paper. Zinc Nitrate powder is added in 500 ml of distilled water and to this lodhra bark extract has been added. The solution is kept in a shaker and the reading was taken for every 2 hrs for analyzing the synthesis of nanoparticles. Lodhra and cinnamon mediated copper nanoparticles were characterized by UV-Visible spectrophotometer and TEM. Further the Lodhra and cinnamon mediated nanoparticles were subjected to DPPH assay to determine the antioxidant activity. Results: Lodhra and cinnamon bark mediated zinc oxide nanoparticles were biosynthesised with ease and showed good anti-inflammatory properties. From the results, It is evident that as the concentration of the nanoparticles increases the anti inflammatory activity also increases. Conclusion: From this study, it is seen that zinc oxide nanoparticles using lodhra and cinnamon bark extract showed significant anti-inflammatory activity against Bovine Serum Albumin and EA assay.