Research article

PCB EXPOSURE MODULATES PANCREATIC INSULIN SIGNALING MECHANISMS IN EXPERIMENTALLY INDUCED TYPE-2 DIABETIC RATS

K. Esha Gayathri, Dr. Abirami Arthanari, Dr. Selvaraj

Online First: November 21, 2022


Aim - The most prevalent type of diabetes is type 2 diabetes, which develops when blood glucose, commonly known as blood sugar, is too high. When there is too much glucose in the blood, not enough reaches the cells.When compared to individuals without the disease, people with type 2 diabetes mellitus (T2DM) have greater levels of persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) in their blood. Polychlorinated biphenyls (PCBs) are a class of organic compounds created by humans that contain carbon, hydrogen, and chlorine atoms. The toxic effects of PCB contamination in aquatic environments appear to be sublethal and chronic. Materials and Methods - Experimental design Group 1 : Control rats (Control rate injected with corn oil intraperitoneally (ip) once daily as a vehicle). Group 2 : Rats received ip injection of A1234 at a dose of 2 mg/kg once daily for 30 days. Results - The PCB treated group has higher fasting blood glucose level indicating hyperglycemia when compared to the control group.Because of reduced antioxidant action of PCB, There is an increase in lipid peroxidation in plasma membrane. The IR mRNA level and Glut 2 are significantly reduced in PCB exposed animals compared to the control group. Conclusion - The results of this study demonstrated that PCB induces insulin resistance in pancreatic beta cells by elevating the lipid peroxidation and reducing the level of antioxidants.Mechanically proving that it acts at the level of insulin signal mechanism

Keywords

Type 2 Diabetes, Insulin, PCBs, Toxicology