STUDY OF SOME BIOCHEMICAL MARKERS FOR PATIENTS WITH CHRONIC KIDNEY DISEASES IN NINEVEH GOVERNORATE

According to several studies, chronic kidney disease (CKD) is highly prevalent worldwide. Patients with chronic kidney diseases on hemodialysis are more likely to have changes in some biochemical variables due to their life style and complications. Our study aimed to study C-reactive protein (CRP) levels, albumin, urea, and creatinine. Also, a study of CRP/Albumin and Urea / Creatinine ratios and glomerular filtration rate (GFR) values to investigate the progression chronic kidney diseases. The study included 159 individuals divided into two groups; first group included (80) patients with chronic kidney disease undergoing dialysis. And second group , included (79) of healthy people as the control group; the ages of both groups ranged from 18-55 years. significantly increase (P≤ 0.01) had been observed in urea and creatinine levels. Also, a significantly increase was established in the urea/creatinine ratio at (P ≤ 0.05) in the patient’s group when compared to the control group. While a significant decrease (P ≤ 0.01) was observed in the level of albumin concentration and glomerular filtration rate. While there was a non-significant difference in the concentration of C-reactive protein and the ratio of CRP / albumin in patients compared to controls Also, negative significant correlation of GFR with creatinine, urea / creatinine ratio and urea concentration at (r= -0.739,p=0.00 ,r= -0.793.p=0.00, r= -0.269,p=0.02 respectively ). We can conclude that chronic kidney disease is related to the high ratios of urea/creatinine, which are more sensitive than biomarkers correlate with disease activity in CKD. While CRP and CRP / albumin ratios are not related directly to kidney dysfunction. Furthermore, GFR values declined considerably (P ≤ 0.01) between the same groups.