Research article

EFFECT OF GLYPHOSATE ON CARDIAC ENZYMES OF GLUCOSE METABOLISM IN MALE RATS

Prateeksha Moharana, Dr. Abirami Arthanari*, Dr . Selvaraj

Online First: November 15, 2022


BACKGROUND: Glyphosate (IUPAC name: N-phosphonomethyl glycine) is a systemic herbicide and crop desiccant with a broad range. It is an organophosphorus chemical, specifically a phosphonate, that inhibits the plant enzyme. Synthase of 5-enolpyruvylshikimate-3-phosphate. AIM: this study aims to evaluate the effect of glyphosate on cardiac enzymes of glucose metabolism MATERIALS AND METHODS: Adult male Albino Wistar rats weighing 150–180 g were used in our study. They were maintained as per the guidelines of the Indian National Law on Animal Care and Use at Biomedical Research unit and laboratory animal center (BRULAC), Saveetha dental college and hospitals, SIMATS, Chennai-77. The Institutional Animal Ethical Committee (IAEC) (Register Number: BRULAC/SDCH/SIMATS/IAEC/8-2021/086) approved all animal-related experimental methods. RESULTS AND DISCUSSION: According to the fasting blood glucose graph, the rat was diagnosed with diabetes in this research. It also revealed that there is hypolipidemia, with HDL being lower and LDL being higher than in the control group. CONCLUSION: According to the findings of this study, glyphosate poisoning affects the enzymes involved in insulin signaling in heart tissue. The mRNA level of pyruvate kinase was lowered following glyphosate exposure, showing that glyphosate toxicity has controlled the enzymes involved in insulin signaling in heart tissue.

Keywords

Glyphosate, cardiac enzymes, glucose metabolism, heart tissues