A POTENTIAL ROLE OF ANTIOXIDANTS (VITAMIN-E) ON STREPTOZOTOCIN-INDUCED PANCREATIC Β-CELL DAMAGE IN ADULT MALE ALBINO RATS

Aim: To evaluate the effect of streptozotocin on the endocrinal functions of the pancreatic gland, and the potential protective effects of vitamin-E in adult male albino rat. Materials and Methods: This study was conducted between March and May, 2022 at animal house of Medical Physiology Department, Al-Azhar Faculty of Medicine, Cairo. 50 adult male albino rats were distributed randomly into 5 equal groups: Normal control group I, Control group II that received olive oil, Control group III (Vitamin-E-treated group), Group IV (streptozotocin-treated group), and Group V (streptozotocin-vitamin E-treated group). Results: Streptozotocin-treated group (group IV) was associated with significant higher levels of serum glucose, MDA, interlukin-1b, and interlukin-6 levels and lowered level of serum insulin and GSH as compared to the control normal groups. this was confirmed by distortion of the normal architecture of the pancreatic tissue with areas of hemorrhage, vacuolation and necrosis in the islets of Langerhans. There were significant amelioration of lipid peroxidation in vitamin-E- streptozotocin -treated group (group V) represented by significant decrease of serum glucose, MDA, interlukin-1b, and interlukin-6 levels, and significant increase of serum insulin and GSH level as compared to the control normal groups. Histopathological changes were improved after receiving vitamin. Conclusion: Vitamin-E could protect the pancreas against streptozotocin -induced alteration in adult male albino rat.