Research article

REVIEW OF THE EFFECT OF VARIOUS BIOLOGICALLY ACTIVE SUBSTANCES ON THE EXPRESSION OF SOD-3 AND HSP-16.2 PROTEINS AND THE ACCUMULATION OF CARBONYLATED PROTEINS IN THE ORGANISM OF CAENORHABDITIS ELEGANS

Irina S. Melentyeva, Elizaveta R. Faskhutdinova, Vyacheslav F. Dolganyuk, Anastasia I. Dmitrieva, Alexander Yu. Prosekov

Online First: December 30, 2022


The problem of aging today is an urgent problem that attracts the attention of scientists from all over the world. Aging is the cause of the appearance in living organisms of diseases such as Alzheimer's disease, Parkinson's disease, neurodegenerative, immune diseases, diabetes, etc. Recently, the attention of scientists has been attracted by medicinal plants, because they have a wide range of morphologically active substances that could be effective in the fight against diseases caused by aging. Polyphenols are recognized as the most promising biologically active substances due to their powerful antioxidant properties. The purpose of this work is to carry out an analytical review of scientific data aimed at searching for plant-derived polyphenols, which in the future will be used as means of ensuring a healthy long life. The review was carried out using databases: Elibrary, Elsiever, PubMed. The inclusion criteria were studies in which the effect of BAS on the expression of proteins SOD-3, HSP-16.2 and carbonylated proteins was studied, since they are responsible for the antioxidant system of the human body. The nematode Caenorhabditis elegans was a model for studying the effect of BAS on the aging process due to a number of advantages, such as a fully sequenced genome, a transparent integument and ease of maintenance in laboratory conditions. As a result, it was found that such polyphenols as caffeic acid, chlorogenic acid, epigallocatechin gallate, genistein, naringenin exhibit antioxidant activity, and, therefore, they are promising compounds for increasing life expectancy. In the future, it is planned to isolate these BAS from plants of the Siberian Federal District in order to study their ability to influence the expression of proteins SOD-3, HSP-16.2 and carbonylated proteins.

Keywords

aging, Caenorhabditis elegans, SOD-3, HSP-16.2, protein carbonylation, medicinal plants, biologically active substances.